{"product_id":"cjc-1295-no-dac","title":"CJC-1295 no DAC","description":"\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Strong → Research Use Only.\" class=\"framer-17icvk9\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"UNBSR8FY_\" class=\"framer-text framer-styles-preset-dbnhlu\"\u003e\u003cem\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Strong → Research Use Only.\" class=\"framer-1j4pnbk\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"joHcNFWNL\" class=\"framer-text framer-styles-preset-1ejfu8l\"\u003eAll products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv data-framer-name=\"Overview\" class=\"framer-6nrd7l\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Overview Header\" class=\"framer-e299os\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eCJC-1295 No DAC Overview\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Overview Body\" class=\"framer-8mbkxy\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003eCJC-1295 No DAC is a modified GHRH(1-29) analog incorporating four amino acid substitutions at positions 2, 8, 15, and 27 designed to confer resistance to dipeptidyl peptidase-4 (DPP-4) degradation while preserving receptor binding affinity. Unlike the DAC-modified version with extended half-life, this variant maintains a shorter duration of action (approximately 30 minutes), enabling amplification of physiologic GH pulse patterns rather than sustained elevation. Research models examine its effects on pituitary GHRH receptor activation, growth hormone secretagogue activity, IGF-1 pathway stimulation, circadian GH rhythm modulation, and metabolic signaling in laboratory settings.\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eTeichman et al. (2006). \u003c\/a\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubm%20ed.ncbi.nlm.nih.gov\/15626560\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eAlba et al. (2005)\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"History\" class=\"framer-1ofh0jr\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"History Header\" class=\"framer-7d5d5p\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eHistory\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"History Body\" class=\"framer-1e0s2rr\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003eCJC-1295 was developed by ConjuChem Biotechnologies in the early 2000s as part of efforts to create GHRH analogs with improved pharmacokinetic properties. The original CJC-1295 with DAC (drug affinity complex) was designed for prolonged activity through albumin binding, reaching phase II experimental programs before discontinuation. The No DAC variant, retaining the core GHRH(1-29) modifications without the albumin-binding complex, emerged as a research tool for studying pulsatile signaling dynamics and has become widely utilized in somatotroph axis investigations.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eTeichman et al. (2006).\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Structure Section 1\" data-border=\"true\" class=\"framer-rpntv3\"\u003e\n\u003cdiv data-framer-name=\"Content\" class=\"framer-dg5g2i\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Structure Header\" class=\"framer-1ccng99\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eCJC-1295 no DAC Structure\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Frame Above Picture\" class=\"framer-u3i1o2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Structure Image\" class=\"framer-hfrwpj\"\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cimg alt=\"\" src=\"https:\/\/framerusercontent.com\/images\/16TWr4RJ9B933B9TbPDDp9eAbtE.png?width=1000\u0026amp;height=1000\" srcset=\"https:\/\/framerusercontent.com\/images\/16TWr4RJ9B933B9TbPDDp9eAbtE.png?scale-down-to=512\u0026amp;width=1000\u0026amp;height=1000 512w,https:\/\/framerusercontent.com\/images\/16TWr4RJ9B933B9TbPDDp9eAbtE.png?width=1000\u0026amp;height=1000 1000w\" sizes=\"calc(max((min(100vw, 980px) - 82px) \/ 1.95, 1px) - 48px)\" height=\"1000\" width=\"1000\" loading=\"lazy\" decoding=\"auto\"\u003e\u003c\/div\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\n\u003cdiv data-framer-name=\"Structure Section 1\" data-border=\"true\" class=\"framer-rpntv3\"\u003e\n\u003cdiv data-framer-name=\"Content\" class=\"framer-dg5g2i\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Molecular Formula\" class=\"framer-qqjc8t\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"ptFoNsxY2\" class=\"framer-text framer-styles-preset-1b1lbsc\"\u003e\u003cstrong\u003eMolecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003eMolecular Weight: 3647.28 g\/mol\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003ePubChem ID: 91976529\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Research Findings\" class=\"framer-1bb7rgf\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Resarch Findings Header\" class=\"framer-138hud5\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eResearch Findings\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Research Findings Body\" class=\"framer-1pwxkmo\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003eCJC-1295 No DAC has been extensively studied in neuroendocrine research, with investigations focusing on pulsatile signaling patterns, pituitary pathway pharmacology, downstream effects, and somatotroph axis regulation in various experimental models. Studies examine its role in amplifying endogenous pulsatile signaling without disrupting native rhythms.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003cstrong class=\"framer-text\"\u003eKey Areas of Research\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cul class=\"framer-text\" dir=\"auto\"\u003e\n\u003cli class=\"framer-text framer-styles-preset-2if8ww\" data-preset-tag=\"p\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eSignaling: Pulsatile, circadian, peak modulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"framer-text framer-styles-preset-2if8ww\" data-preset-tag=\"p\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003ePharmacology: Target binding, somatotroph, cAMP\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"framer-text framer-styles-preset-2if8ww\" data-preset-tag=\"p\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eDownstream: Hepatic signaling, cascades, activation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"framer-text framer-styles-preset-2if8ww\" data-preset-tag=\"p\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eEndocrine: Lipolysis, nitrogen, protein synthesis\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003eTogether, these investigations demonstrate CJC-1295 No DAC's ability to modulate pulsatile endocrine signaling patterns. As a short-acting GHRH analog, it provides a research framework for examining hypothalamic-pituitary-somatotroph axis function, pulsatile dynamics, and downstream signaling in diverse experimental paradigms.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eTeichman et al., Clinical Endocrinology, 2006\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubm%20ed.ncbi.nlm.nih.gov\/15626560\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eAlba et al., The Journal of Clinical Endocrinology \u0026amp; Metabolism, 2005\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16713307\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eIonescu \u0026amp; Frohman, Growth Hormone \u0026amp; IGF Research, 2006\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"References\" data-border=\"true\" class=\"framer-14l2n57\"\u003e\n\u003cdiv data-framer-name=\"Content\" class=\"framer-15p1962\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Research Use Only\" class=\"framer-1ecatqh\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eReferences\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eTeichman S.L. et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long- acting analog of GH-releasing hormone, in healthy adults. Clinical Endocrinology, 64(3):342-349.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubm%20ed.ncbi.nlm.nih.gov\/15626560\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eAlba M. et al. (2005). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. The Journal of Clinical Endocrinology \u0026amp; Metabolism, 90(4):2171-2180.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003c\/a\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16713307\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eIonescu M. \u0026amp; Frohman L.A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. Growth Hormone \u0026amp; IGF Research, 16(3):201-206\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Peptiders","offers":[{"title":"10mg \/ Single Vial","offer_id":44973192478806,"sku":null,"price":69.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ Pack of 10","offer_id":44973192511574,"sku":null,"price":619.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/8787\/7206\/files\/CJC-1295noDAC.avif?v=1781647504","url":"https:\/\/peptidersresearch.com\/products\/cjc-1295-no-dac","provider":"Peptiders Researcher","version":"1.0","type":"link"}