{"product_id":"kisspeptin","title":"Kisspeptin","description":"\u003cdiv class=\"framer-17icvk9\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-dbnhlu\" data-styles-preset=\"UNBSR8FY_\" dir=\"auto\"\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1j4pnbk\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1ejfu8l\" data-styles-preset=\"joHcNFWNL\" dir=\"auto\"\u003eAll products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-6nrd7l\" data-framer-name=\"Overview\"\u003e\n\u003cdiv class=\"framer-e299os\" data-framer-name=\"Overview Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eKisspeptin-10 Overview\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-8mbkxy\" data-framer-name=\"Overview Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eKisspeptin represents a central signaling molecule in the hypothalamic-pituitary-gonadal (HPG) axis, acting as a key modulator of neuroendocrine signaling. As a family of peptides ranging from kisspeptin-10 to kisspeptin-54, these molecules bind to their target receptor (KISS1R) and play essential roles in neuroendocrine research. Through KISS1R activation on target neurons, kisspeptin influences pulsatile signaling dynamics, developmental pathway initiation, and endocrine regulation. Research models examine its role in neuroendocrine signaling cascades, feedback loop dynamics, and developmental biology.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25036718\/\" rel=\"noopener\" target=\"_blank\"\u003eJayasena et al. (2014). Trevisan et al. (2018).\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1ofh0jr\" data-framer-name=\"History\"\u003e\n\u003cdiv class=\"framer-7d5d5p\" data-framer-name=\"History Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eHistory\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1e0s2rr\" data-framer-name=\"History Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eKisspeptin was initially identified in 1996 as a metastasis suppressor gene product in melanoma research, leading to its original name 'metastin.' The critical neuroendocrine role was discovered in 2003 when loss-of-function mutations in KISS1 and KISS1R were found to be associated with HPG axis signaling disruption in experimental and observational studies. This breakthrough established kisspeptin as a key modulator of endocrine signaling and sparked extensive neuroendocrine research.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9788075\/\" rel=\"noopener\" target=\"_blank\"\u003eMills \u0026amp; Dhillo (2022).\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-rpntv3\" data-border=\"true\" data-framer-name=\"Structure Section 1\"\u003e\n\u003cdiv class=\"framer-dg5g2i\" data-framer-name=\"Content\"\u003e\n\u003cdiv class=\"framer-1ccng99\" data-framer-name=\"Structure Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eKisspeptin-10 Structure\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-u3i1o2\" data-framer-name=\"Frame Above Picture\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-hfrwpj\" data-framer-name=\"Structure Image\"\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cimg decoding=\"auto\" loading=\"lazy\" width=\"993\" height=\"399\" sizes=\"calc(max((min(100vw, 980px) - 82px) \/ 1.95, 1px) - 48px)\" srcset=\"https:\/\/framerusercontent.com\/images\/QtMctOm2GNJkZpwFyFCtxeP7l6g.png?scale-down-to=512\u0026amp;width=993\u0026amp;height=399 512w,https:\/\/framerusercontent.com\/images\/QtMctOm2GNJkZpwFyFCtxeP7l6g.png?width=993\u0026amp;height=399 993w\" src=\"https:\/\/framerusercontent.com\/images\/QtMctOm2GNJkZpwFyFCtxeP7l6g.png?width=993\u0026amp;height=399\" alt=\"\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-ay3afz\" data-framer-name=\"Frame Below Picture\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-3wrgap\" data-framer-name=\"CAS #\" data-framer-component-type=\"RichTextContainer\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-qqjc8t\" data-framer-name=\"Molecular Formula\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003eMolecular Formula: C₆₃H₈₃N₁₇O₁₄\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003eMolecular Weight: 1302.45 g\/mol\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003ePubChem ID: 25240297\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-1bb7rgf\" data-framer-name=\"Research Findings\"\u003e\n\u003cdiv class=\"framer-138hud5\" data-framer-name=\"Resarch Findings Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eResearch Findings\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1pwxkmo\" data-framer-name=\"Research Findings Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eKisspeptin has been extensively studied in neuroendocrine research, with investigations focusing on hypothalamic signaling regulation, developmental pathway mechanisms, endocrine modulation, and HPG axis dynamics in various experimental models. Studies examine kisspeptin's interactions with neurokinin B and dynorphin in the hypothalamic KNDy neuron system.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003cstrong class=\"framer-text\"\u003eKey Areas of Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\" class=\"framer-text\"\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eNeuroendocrine: Pulsatile signaling, cascade dynamics, pathway initiation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eHypothalamic: KNDy neurons, arcuate nucleus, median eminence\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003ePharmacology: KISS1R activation, signaling pathways, distribution\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eDevelopmental: Maturation pathways, axis establishment, endocrine dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTogether, these findings demonstrate kisspeptin's fundamental role in neuroendocrine biology. Through its upstream regulation of hypothalamic signaling, kisspeptin provides a research framework for understanding endocrine cascade dynamics, neuroendocrine integration, and developmental signaling across experimental paradigms.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2018.00148\/\" rel=\"noopener\" target=\"_blank\"\u003eTrevisan et al., Frontiers in Endocrinology, 2018\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-14l2n57\" data-border=\"true\" data-framer-name=\"References\"\u003e\n\u003cdiv class=\"framer-15p1962\" data-framer-name=\"Content\"\u003e\n\u003cdiv class=\"framer-1ecatqh\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eReferences\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-8qnss1\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25036718\/\" rel=\"noopener\" target=\"_blank\"\u003eJayasena C.N. et al. (2014). Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation, 124(8):3667-3677. \u003c\/a\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9788075\/\" rel=\"noopener\" target=\"_blank\"\u003eMills E.G. \u0026amp; Dhillo W.S. (2022). Translating kisspeptin and neurokinin B biology into new therapies for reproductive health. Journal of Neuroendocrinology, 34(10):e13201. \u003c\/a\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2018.00148\/\" rel=\"noopener\" target=\"_blank\"\u003eTrevisan C.M. et al. (2018). Role of kisspeptin and neurokinin B in puberty in female non-human primates. Frontiers in Endocrinology, 9:148.\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Peptiders","offers":[{"title":"10mg \/ Single Vial","offer_id":44973112262742,"sku":null,"price":59.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ Pack of 10","offer_id":44973112295510,"sku":null,"price":529.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/8787\/7206\/files\/kisspeptin.avif?v=1781651381","url":"https:\/\/peptidersresearch.com\/products\/kisspeptin","provider":"Peptiders Researcher","version":"1.0","type":"link"}