{"product_id":"mots-c","title":"MOTS-c","description":"\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Strong → Research Use Only.\" class=\"framer-17icvk9\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"UNBSR8FY_\" class=\"framer-text framer-styles-preset-dbnhlu\"\u003e\u003cem\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Strong → Research Use Only.\" class=\"framer-1j4pnbk\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"joHcNFWNL\" class=\"framer-text framer-styles-preset-1ejfu8l\"\u003eAll products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"History Header\" class=\"framer-7d5d5p\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eHistory\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"History Body\" class=\"framer-1e0s2rr\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003eMOTS-c was first described in 2015 following the discovery of short open reading frames encoded within mitochondrial DNA. Identified as a mitochondrial-derived peptide with signaling activity, it has since been studied for its ability to activate AMPK pathways and support molecular stress resistance. This discovery expanded the understanding of mitochondria as signaling organelles beyond energy production, positioning MOTS-c as a key peptide in mitochondrial biology research.\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\" dir=\"auto\"\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26858423\/\" class=\"framer-text framer-styles-preset-dxoa8s\" target=\"_blank\"\u003eLee C., Yen K., Cohen P. (2016).\u003c\/a\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Structure Header\" class=\"framer-1ccng99\"\u003e\n\u003ch2 dir=\"auto\" data-styles-preset=\"Ze7_hb2TJ\" class=\"framer-text framer-styles-preset-17n1ut5\"\u003eMOTS-c\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Frame Above Picture\" class=\"framer-u3i1o2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv data-framer-name=\"Structure Image\" class=\"framer-hfrwpj\"\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cimg alt=\"\" src=\"https:\/\/framerusercontent.com\/images\/dEoWBGv7ZeYHcOjlHL9tWjL4v0E.svg?width=1000\u0026amp;height=1000\" srcset=\"https:\/\/framerusercontent.com\/images\/dEoWBGv7ZeYHcOjlHL9tWjL4v0E.svg?scale-down-to=512\u0026amp;width=1000\u0026amp;height=1000 512w,https:\/\/framerusercontent.com\/images\/dEoWBGv7ZeYHcOjlHL9tWjL4v0E.svg?width=1000\u0026amp;height=1000 1000w\" sizes=\"calc(max((min(100vw, 980px) - 82px) \/ 1.95, 1px) - 48px)\" height=\"433\" width=\"433\" loading=\"lazy\" decoding=\"auto\"\u003e\u003c\/div\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cem\u003e\u003cstrong\u003eMolecular Formula: C₁₄₉H₂₆₀N₄₆O₄₆S₂\u003c\/strong\u003e\u003c\/em\u003e\u003c\/div\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\n\u003cdiv data-framer-component-type=\"RichTextContainer\" data-framer-name=\"Molecular Weight\" class=\"framer-q2h1nh\"\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"ptFoNsxY2\" class=\"framer-text framer-styles-preset-1b1lbsc\"\u003e\u003cem\u003e\u003cstrong\u003eMolecular Weight: 2171.5 g\/mol\u003c\/strong\u003e\u003c\/em\u003e\u003cbr\u003e\u003cem\u003e\u003cstrong\u003ePubChem ID: 91808068\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-138hud5\" data-framer-name=\"Resarch Findings Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eResearch Findings\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1pwxkmo\" data-framer-name=\"Research Findings Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eMOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003cstrong class=\"framer-text\"\u003eKey Areas of Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\" class=\"framer-text\"\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eMitochondrial: AMPK, signaling, pathway dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eMolecular: Mitochondrial function, stress response, remodeling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eSystemic: Signaling, resilience, viability\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTogether, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and systemic resilience in laboratory settings.\u003cbr\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/doi.org\/10.1016\/j.cmet.2015.03.009\" rel=\"noopener\" target=\"_blank\"\u003eLee C. et al., 2015\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-14l2n57\" data-border=\"true\" data-framer-name=\"References\"\u003e\n\u003cdiv class=\"framer-15p1962\" data-framer-name=\"Content\"\u003e\n\u003cdiv class=\"framer-1ecatqh\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eReferences\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1383kxn\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-8qnss1\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25738459\/\" rel=\"noopener\" target=\"_blank\"\u003eLee C. et al. (2015). \u003cem class=\"framer-text\"\u003eMOTS-c: a mitochondrial-encoded regulator of metabolism and stress response.\u003c\/em\u003e Cell Metab, 21(3):443–454.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26858423\/\" rel=\"noopener\" target=\"_blank\"\u003eLee C., Yen K., Cohen P. (2016). \u003cem class=\"framer-text\"\u003eMitochondrial peptides as novel regulators of metabolism.\u003c\/em\u003e J Physiol, 594(15):5375–5381.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28604693\/\" rel=\"noopener\" target=\"_blank\"\u003eZhu S. et al. (2017). \u003cem class=\"framer-text\"\u003eMOTS-c enhances metabolic homeostasis and mitochondrial function in laboratory models.\u003c\/em\u003e Aging Cell, 16(5): 968–977.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29445185\/\" rel=\"noopener\" target=\"_blank\"\u003eKim K.H. et al. (2018). \u003cem class=\"framer-text\"\u003eMOTS-c and exercise-induced mitochondrial signaling.\u003c\/em\u003e J Mol Med, 96(7): 699–709. \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp dir=\"auto\" data-styles-preset=\"ptFoNsxY2\" class=\"framer-text framer-styles-preset-1b1lbsc\"\u003e\u003cem\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Peptiders","offers":[{"title":"10mg \/ Single Vial","offer_id":44973304217686,"sku":null,"price":49.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ Pack of 10","offer_id":44973304250454,"sku":null,"price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/8787\/7206\/files\/MOTS-c.avif?v=1781639796","url":"https:\/\/peptidersresearch.com\/products\/mots-c","provider":"Peptiders Researcher","version":"1.0","type":"link"}