{"product_id":"pt-141","title":"PT-141","description":"\u003cdiv class=\"framer-17icvk9\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-dbnhlu\" data-styles-preset=\"UNBSR8FY_\" dir=\"auto\"\u003e\u003cem\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1j4pnbk\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1ejfu8l\" data-styles-preset=\"joHcNFWNL\" dir=\"auto\"\u003eAll products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-6nrd7l\" data-framer-name=\"Overview\"\u003e\n\u003cdiv class=\"framer-e299os\" data-framer-name=\"Overview Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003ePT-141 Overview\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-8mbkxy\" data-framer-name=\"Overview Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003ePT-141, also known as Bremelanotide, is a synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH). It is studied in laboratory and preclinical models for its ability to activate melanocortin receptors (MC3R and MC4R), which are involved in neuroendocrine signaling, energy regulation, and vascular pathways.\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8874162\/\" rel=\"noopener\" target=\"_blank\"\u003eDorr R.T. et al. (1996).\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1ofh0jr\" data-framer-name=\"History\"\u003e\n\u003cdiv class=\"framer-7d5d5p\" data-framer-name=\"History Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eHistory\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1e0s2rr\" data-framer-name=\"History Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003ePT-141 was developed through research into melanocortin-class peptides, originally derived from modifications of Melanotan II. While Melanotan II was primarily studied for its pigmentation pathway properties, PT-141 was synthesized to focus on central target receptor activity. Since its discovery, PT-141 has been investigated in models of neuroendocrine function, vascular signaling, and peptide-receptor dynamics.\u003cbr class=\"framer-text\"\u003e\u003cbr class=\"framer-text\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12192087\/\" rel=\"noopener\" target=\"_blank\"\u003eShadiack A.M. et al. (2002).\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-rpntv3\" data-border=\"true\" data-framer-name=\"Structure Section 1\"\u003e\n\u003cdiv class=\"framer-dg5g2i\" data-framer-name=\"Content\"\u003e\n\u003cdiv class=\"framer-1ccng99\" data-framer-name=\"Structure Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003ePT-141 Structure\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-u3i1o2\" data-framer-name=\"Frame Above Picture\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-hfrwpj\" data-framer-name=\"Structure Image\"\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cimg decoding=\"auto\" loading=\"lazy\" width=\"978\" height=\"510\" sizes=\"calc(max((min(100vw, 980px) - 82px) \/ 1.95, 1px) - 48px)\" srcset=\"https:\/\/framerusercontent.com\/images\/AcwDamU6evvAfMNVhfLRL2XdLo8.svg?scale-down-to=512\u0026amp;width=978\u0026amp;height=510 512w,https:\/\/framerusercontent.com\/images\/AcwDamU6evvAfMNVhfLRL2XdLo8.svg?width=978\u0026amp;height=510 978w\" src=\"https:\/\/framerusercontent.com\/images\/AcwDamU6evvAfMNVhfLRL2XdLo8.svg?width=978\u0026amp;height=510\" alt=\"\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-3wrgap\" data-framer-name=\"CAS #\" data-framer-component-type=\"RichTextContainer\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-qqjc8t\" data-framer-name=\"Molecular Formula\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003eMolecular Formula: C₅₀H₆₈N₁₄O₁₀\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003eMolecular Weight: 1025.2 g\/mol\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003ePubChem ID: 6918280\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1bb7rgf\" data-framer-name=\"Research Findings\"\u003e\n\u003cdiv class=\"framer-138hud5\" data-framer-name=\"Resarch Findings Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eResearch Findings\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1pwxkmo\" data-framer-name=\"Research Findings Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003ePT-141 has been studied in neurological, endocrine, and systemic models, with research highlighting its activity in target receptor pathways, neuroendocrine signaling, and systemic dynamics. Studies also report effects on central nervous system activity, endocrine modulation, and vascular responses in preclinical settings.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003cstrong class=\"framer-text\"\u003eKey Areas of Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\" class=\"framer-text\"\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eNeurological: CNS activity, signaling, pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eEndocrine: Modulation, signaling dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eSystemic: Vascular responses, viability, resilience\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTogether, these findings suggest experimental potential for PT-141 across neurological, endocrine, and systemic pathways. By engaging target receptor pathways and influencing neuroendocrine activity, PT-141 provides a versatile platform for research into signaling biology, systemic dynamics, and central pathway characterization in laboratory settings.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/doi.org\/10.1111\/j.1743-6109.2004.04061.x\" rel=\"noopener\" target=\"_blank\"\u003eShadiack A.M. et al., 2004\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-14l2n57\" data-border=\"true\" data-framer-name=\"References\"\u003e\n\u003cdiv class=\"framer-15p1962\" data-framer-name=\"Content\"\u003e\n\u003cdiv class=\"framer-1ecatqh\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eReferences\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-8qnss1\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8874162\/\" rel=\"noopener\" target=\"_blank\"\u003eDorr R.T. et al. (1996). \u003cem class=\"framer-text\"\u003ePharmacology and receptor activity of melanocortin peptides in preclinical models.\u003c\/em\u003e J Invest Dermatol, 106(6):1125–1131.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12192087\/\" rel=\"noopener\" target=\"_blank\"\u003eShadiack A.M. et al. (2002). \u003cem class=\"framer-text\"\u003eMelanocortin receptor agonists and their role in neuroendocrine signaling.\u003c\/em\u003e J Pharmacol Exp Ther, 301(1):349–355.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15916786\/\" rel=\"noopener\" target=\"_blank\"\u003eKing S.H. et al. (2005). \u003cem class=\"framer-text\"\u003eReceptor pharmacology of PT-141 at MC3R and MC4R sites.\u003c\/em\u003e Peptides, 26(6):1068–1073. \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Peptiders","offers":[{"title":"10mg \/ Single Vial","offer_id":44973107576918,"sku":null,"price":49.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ Pack of 10","offer_id":44973107609686,"sku":null,"price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/8787\/7206\/files\/PT-141single.avif?v=1781651813","url":"https:\/\/peptidersresearch.com\/products\/pt-141","provider":"Peptiders Researcher","version":"1.0","type":"link"}