{"product_id":"tb-500","title":"TB-500","description":"\u003cdiv class=\"framer-17icvk9\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-dbnhlu\" data-styles-preset=\"UNBSR8FY_\" dir=\"auto\"\u003e\u003cem\u003e\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1j4pnbk\" data-framer-name=\"Strong → Research Use Only.\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1ejfu8l\" data-styles-preset=\"joHcNFWNL\" dir=\"auto\"\u003eAll products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-6nrd7l\" data-framer-name=\"Overview\"\u003e\n\u003cdiv class=\"framer-e299os\" data-framer-name=\"Overview Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eTB-500 Overview\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-8mbkxy\" data-framer-name=\"Overview Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTB-500 is a synthetic peptide fragment derived from thymosin beta-4, a naturally occurring protein studied for its role in molecular signaling and pathway dynamics. Research has focused on its potential influence on matrix remodeling, angiogenesis, and molecular migration in preclinical and laboratory models. TB-500 is of particular interest in investigations involving connective tissue, structural dynamics, and extracellular matrix pathways.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15894964\/\" rel=\"noopener\" target=\"_blank\"\u003eGoldstein A.L. et al. (2005). \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1ofh0jr\" data-framer-name=\"History\"\u003e\n\u003cdiv class=\"framer-7d5d5p\" data-framer-name=\"History Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eHistory\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1e0s2rr\" data-framer-name=\"History Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eThymosin Beta-4, the parent protein of TB-500, was first isolated in the 1960s by Allan L. Goldstein and colleagues during research into thymus-derived peptides. TB-500 was later synthesized as a research fragment to enable focused study on Tβ4's signaling functions. Since its development, it has been investigated across models of angiogenesis, structural dynamics, and molecular migration, with growing interest in its systemic regulatory potential.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22820747\/\" rel=\"noopener\" target=\"_blank\"\u003eGoldstein A.L., Hannappel E. et al. (2012).\u003c\/a\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-1ccng99\" data-framer-name=\"Structure Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eTB-500 Structure\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-u3i1o2\" data-framer-name=\"Frame Above Picture\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-hfrwpj\" data-framer-name=\"Structure Image\"\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\u003cimg decoding=\"auto\" loading=\"lazy\" width=\"728\" height=\"352\" sizes=\"calc(max((min(100vw, 980px) - 82px) \/ 1.95, 1px) - 48px)\" srcset=\"https:\/\/framerusercontent.com\/images\/zSHSzqmQXOwl7fG6SVHFD1cssvM.gif?scale-down-to=512\u0026amp;width=728\u0026amp;height=352 512w,https:\/\/framerusercontent.com\/images\/zSHSzqmQXOwl7fG6SVHFD1cssvM.gif?width=728\u0026amp;height=352 728w\" src=\"https:\/\/framerusercontent.com\/images\/zSHSzqmQXOwl7fG6SVHFD1cssvM.gif?width=728\u0026amp;height=352\" alt=\"\"\u003e\u003c\/div\u003e\n\u003cdiv data-framer-background-image-wrapper=\"true\"\u003e\n\u003cdiv class=\"framer-qqjc8t\" data-framer-name=\"Molecular Formula\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003eMolecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-q2h1nh\" data-framer-name=\"Molecular Weight\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003eMolecular Weight: 4963.5 g\/mol\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-5d66tv\" data-framer-name=\"PubChem ID\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-1b1lbsc\" data-styles-preset=\"ptFoNsxY2\" dir=\"auto\"\u003e\u003cstrong\u003ePubChem ID: 16132321\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-138hud5\" data-framer-name=\"Resarch Findings Header\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eResearch Findings\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1pwxkmo\" data-framer-name=\"Research Findings Body\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTB-500 has been studied in structural, vascular, epithelial, and systemic models, with research exploring its roles in collagen organization, extracellular matrix remodeling, angiogenesis, molecular migration, and pathway activity in preclinical settings.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003cstrong class=\"framer-text\"\u003eKey Areas of Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\" class=\"framer-text\"\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eStructural: Collagen, matrix, tendon\/ligament\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eVascular: Angiogenesis, nitric oxide, remodeling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eEpithelial: Migration, signaling, matrix\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-preset-tag=\"p\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-2if8ww\"\u003eSystemic: Signaling, viability, pathway dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003eTogether, these findings suggest broad experimental utility for TB-500 across multiple biological pathways. By engaging structural and vascular processes and supporting epithelial and systemic responses, TB-500 provides a versatile platform for investigating molecular remodeling, pathway dynamics, and resilience in laboratory settings.\u003c\/p\u003e\n\u003cp dir=\"auto\" class=\"framer-text framer-styles-preset-2if8ww\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/scholar.google.com\/scholar?q=Hsieh+M.-J.+2017+thymosin+beta-4\" rel=\"noopener\" target=\"_blank\"\u003eHsieh M.-J. et al., 2017\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv class=\"framer-1ecatqh\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003ch2 class=\"framer-text framer-styles-preset-17n1ut5\" data-styles-preset=\"Ze7_hb2TJ\" dir=\"auto\"\u003eReferences\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"framer-1383kxn\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"framer-8qnss1\" data-framer-name=\"Research Use Only\" data-framer-component-type=\"RichTextContainer\"\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15894964\/\" rel=\"noopener\" target=\"_blank\"\u003eGoldstein A.L. et al. (2005). \u003cem class=\"framer-text\"\u003eThymosin beta-4 and tissue regeneration: potential mechanisms of action.\u003c\/em\u003e Ann N Y Acad Sci.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22820747\/\" rel=\"noopener\" target=\"_blank\"\u003eGoldstein A.L., Hannappel E. et al. (2012). \u003cem class=\"framer-text\"\u003eThymosin beta-4: a multifunctional regenerative peptide.\u003c\/em\u003e Expert Opin Biol Ther, 12(1):37–51.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10069817\/\" rel=\"noopener\" target=\"_blank\"\u003eMalinda K.M. et al. (1999). \u003cem class=\"framer-text\"\u003eThymosin beta-4 stimulates directional migration of human umbilical vein endothelial cells.\u003c\/em\u003e FASEB J, 13(6):693–701.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17525364\/\" rel=\"noopener\" target=\"_blank\"\u003eSmart N. et al. (2007). \u003cem class=\"framer-text\"\u003eThymosin beta-4 induces adult epicardial progenitor mobilization and neovascularization.\u003c\/em\u003e Nature, 445(7124):177–182.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14678982\/\" rel=\"noopener\" target=\"_blank\"\u003ePhilp D. et al. (2003). \u003cem class=\"framer-text\"\u003eThymosin beta-4 promotes dermal wound healing.\u003c\/em\u003e J Invest Dermatol, 121(4):694–701. \u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"framer-text framer-styles-preset-pl80se\"\u003e\u003ca class=\"framer-text framer-styles-preset-dxoa8s\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15362021\/\" rel=\"noopener\" target=\"_blank\"\u003eBock-Marquette I. et al. (2004). \u003cem class=\"framer-text\"\u003eThymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and repair.\u003c\/em\u003e Nature, 432(7016):466–\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Peptiders","offers":[{"title":"10mg \/ Single Vial","offer_id":44973352910934,"sku":null,"price":69.0,"currency_code":"USD","in_stock":true},{"title":"10mg \/ Pack of 10","offer_id":44973352943702,"sku":null,"price":619.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/8787\/7206\/files\/TB-500single.avif?v=1781638319","url":"https:\/\/peptidersresearch.com\/products\/tb-500","provider":"Peptiders Researcher","version":"1.0","type":"link"}