MOTS-c
MOTS-c
Research Use Only
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MOTS-c Overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA. It is studied in preclinical and laboratory models for its role in mitochondrial signaling, AMPK pathway activation, and cellular stress resistance. As a member of the class of mitochondrial-derived peptides, MOTS-c is of particular interest in research on metabolic regulation and mitochondrial biology.
History
MOTS-c was first described in 2015 following the discovery of short open reading frames encoded within mitochondrial DNA. Identified as a mitochondrial-derived peptide with signaling activity, it has since been studied for its ability to activate AMPK pathways and support molecular stress resistance. This discovery expanded the understanding of mitochondria as signaling organelles beyond energy production, positioning MOTS-c as a peptide of interest in mitochondrial biology research.
MOTS-c
Molecular Weight: 2174.6 g/mol
CAS: 1627580-64-6
PubChem ID: 91808068
Research Findings
MOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.
Key Areas of Research:
- Mitochondrial: AMPK, signaling, pathway dynamics
- Molecular: Mitochondrial function, stress response, remodeling
- Systemic: Signaling, resilience, viability
Together, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and systemic resilience in laboratory settings.
References
Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454.
Reynolds, J.C., et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470.
Zheng, Y., Wang, T., & Wei, Z. (2023). MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 14, 1120533.